It showed that a low dose of the sedative antidepressant trazodone, 50 mg, given at night for two weeks, may increase the total time spent asleep each night (an average of 43 minutes more in the trial) and may improve sleep efficiency (the percentage of time in bed spent sleeping).
#Trazodone for insomnia vs depression trial
Tell your doctor if this advice does not help or the side effects do not go away. The trazodone trial had only 30 participants.
There are things you can do to help cope with them: Feeling sleepy or tired. The FDA recommends immediate medical care if an erection lasts longer than 4 hours. Some of the common side effects of trazodone will gradually get better as your body gets used to it. Also seek immediate medical care if have any suicidal thoughts or behavior or if you have symptoms of serotonin syndrome, a severe allergic reaction or hyponatremia. Seek immediate medical attention if you feel dizzy while sitting or lying down, if you faint, if your heart palpitations do not go away in a few minutes or if you have bleeding from the nose or digestive tract. Trazodone is approved for treating depression and eszopiclone for treating insomnia. The SSRIs can cause insomnia and worsen sleep quality, but bupropion is surprisingly more favorable for sleep. It also improves the deep, restorative phase of sleep. Do not operate machinery, drive or do any other possibly dangerous activities until you are sure that trazodone will not cause these effects 1 2 3.Ĭontact your doctor if you feel dizzy when standing or notice heart palpitations while taking trazodone 3. All three contain sleep-inducing ingredients but work in different ways. Quetiapine carries too many risks to recommend it for primary insomnia, but it is appropriate for antidepressant augmentation (150 to 300 mg qhs). Trazodone may produce drowsiness and slow your ability to think or perform physical activities 3. The FDA-approved prescribing information states that trazodone should not be started until you have been off all MAOIs for at least 14 days 3. If you take MAOIs, they should be discontinued before starting trazodone because of the possibility of serotonin syndrome 3. Seizures, coma and death can occur when sodium levels are very low.Like all medications, trazodone may trigger an allergic reaction 3.Hyponatremia is most likely in people who are older or taking water pills. Seizures, coma and death can occur when sodium levels are very low. This can lead to headaches, confusion and weakness.
Trazodone sometimes causes sodium levels in the blood to fall, producing hyponatremia 3. Like all medications, trazodone may trigger an allergic reaction 3. Slowly reducing the dose instead of suddenly stopping trazodone will help avoid these symptoms 3.
This is the body's natural response to falling serotonin levels. When trazodone is taken for a prolonged time, abruptly discontinuing it could lead to a type of withdrawal reaction 3. Background Sleep disturbance is a common complaint in major depressive disorder (MDD) including impairment of both subjective and objective parameters.
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